Ⅰ型补体受体抗体(C3b/C4b受体抗体)-抗体-抗体-生物在线
北京索莱宝科技有限公司
Ⅰ型补体受体抗体(C3b/C4b受体抗体)

Ⅰ型补体受体抗体(C3b/C4b受体抗体)

商家询价

产品名称: Ⅰ型补体受体抗体(C3b/C4b受体抗体)

英文名称: CD35

产品编号: bs-10144R

产品价格: null

产品产地: 北京

品牌商标: BIOSS

更新时间: 2025-02-06T15:55:16

使用范围: WB=1:100-500,ELISA=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,

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This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.